Test ID: ZG558
Component(s): Z1076 Clozapine, Serum LOINC: 6896-5, Z2913 Norclozapine, Serum LOINC: 10992-6, Z2914 Total(Cloz+Norcloz) LOINC 12375-2
CPT code: 80159
LOINC:
Specimen Type: Red, Lav(EDTA) OR green(heparin). NO SST
Frequency: 2 – 4 days working day.
Instructions: 1 mL Serum or Plasma from Red, Lav(EDTA) OR green(heparin). Ambient, Do not use a gel tube. Min 0.3 mL.
Text: Evaluate toxicity; monitor therapeutic levels. Adverse effects: significantly increases mean levels of glucose, triglycerides & C-peptide. Issued by the FDA: Patients being treated with clozapine must have a baseline WBC & absolute neutrophil count before treatment & regular WBC counts/ANCs during treatment & for at least four weeks after discontinuation.
Methodology: Liquid chromatography/tandem mass spectrometry (LC/MS-MS)